Non-invasive Evaluation of Portal Pressure by MRI (ENIP)

Toulouse University Hospital

Status: Terminated

Conditions: Chronic Liver Disease

Treatments: Procedure: Intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT02530567

RC31/14/7318

University Hospital Toulouse

Details and patient eligibility

About

The objective of this research is to study the correlation between the portosystemic pressure gradient and azygos blood flow measured by MRI.

Full description

All patients will benefit from:

• Pressure gradient measurement portosystemic
• MRI measurement of azygos flow, aortic, portals, spleen and lower cellar
• Liver biopsy
• Laboratory tests

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Suspicion of chronic liver disease
• Indication to perform a liver biopsy transjugular
• Patient able to consent

Exclusion criteria

• contraindication to MRI:
• Holders of a pacemaker or a defibrillator, an implanted material activated by electrical, magnetic or mechanical
• Holders of hemostatic clips intracerebral aneurysms or carotid arteries, bearing orthopedic implants
• claustrophobic
• Severe hepatic encephalopathy
• Inability to MRI in the week surrounding the first jugular

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

Intervention

Experimental group

Description:

The measurement of portosystemic pressure gradient will be performed before liver biopsy. Then liver biopsy is performed. The MRI was performed on the day of biopsy or within one week around the completion of the biopsy. The MRI machine used is the Siemens 3T.

Treatment:

Procedure: Intervention