Non-invasive Evaluation of Volume Status Using Exhaled Carbon Dioxide and Pulse Contour Analysis

University of Oslo (UIO)

Status: Completed

Conditions: Changes in Cardiac Output

Treatments: Other: Ventricular pacing and passive leg raise

Study type: Interventional

Funder types: Other

Identifiers

NCT02070861

2013/1605

Details and patient eligibility

About

The investigators hypothesize that changes in blood circulation can be reflected by exhaled CO2 provided CO2-production in the tissues and ventilation from the lungs are stable. The investigators want to explore changes in cardiac output (the amount of blood being pumped out of the heart each minute) in patients using different devices: an esophagus ultrasound device measuring cardiac output, a finger cuff measuring blood pressure and cardiac output, and exhaled carbondioxide in the patients' breath measured by the ventilator.

The investigators investigate patients after bypass surgery or heart valve replacement, and induce changes in cardiac output with passive leg raise or ventricular pacing.

Full description

Measurements with the finger cuff (pulse contour analyses) were aborted due to technical difficulties.

Enrollment: 33 patients

Sex: All

Ages: 18 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Persons 18 years or older scheduled to undergo arteriocoranary bypass surgery or aortic valve replacement.

Exclusion criteria

• Esophageal pathology, EF <40%

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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33 participants in 1 patient group

Comparing cardiac output changes

Experimental group

Description:

Explore the relationship between changes in cardiac output measured with eosophagal Doppler, the volume-clamp-method and exhaled CO2 during ventricular pacing and passive leg raise. Measurements with the volume-clamp-method were aborted due to technological difficulties.

Treatment:

Other: Ventricular pacing and passive leg raise