Non-invasive Glioma Characterization Through Molecular Imaging

University of Miami

Status: Enrolling

Conditions: Malignant Primary Brain Tumor; Glioma; Brain Tumor; Malignant Glioma; Primary Brain Tumor

Treatments: Device: 3T MRI Scanner

Study type: Interventional

Funder types: Other

Identifiers

NCT03684109

20180606

Details and patient eligibility

About

MRI-based sequences can provide non-invasive quantification of intratumoral 2-hydroxyglutarate (2HG) distribution and tumor cellularity in human gliomas and help guide the development of novel glioma therapies.

Full description

This is a pilot study aiming at developing and optimizing MRI-based sequences to provide non-invasive quantification of intratumoral 2-hydroxyglutarate (2HG) distribution and tumor cellularity in human gliomas and help guide the development of novel glioma therapies.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults (≥18 year old)
• Subjects with suspected or confirmed gliomas and who will have a medically indicated biopsy or resection of his/her brain lesion.

Exclusion criteria

• Adults unable to consent
• Individuals who are not yet adults (infants, children, teenagers)
• Pregnant women
• Patients unable to have MRI done

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

IDH-Mutant Glioma Patients

Experimental group

Description:

Patients who have suspected or confirmed gliomas and are scheduled to undergo biopsy or resection of their brain tumors will receive a 3 Tesla (3T) Magnetic Resonance Imaging (MRI) scan of their brain.

Treatment:

Device: 3T MRI Scanner