Non-invasive Measurement of Cerebral Dynamic Autoregulation (TOMCAT)

University of Pennsylvania

Status: Completed

Conditions: Stroke

Treatments: Device: Thigh Cuff

Study type: Interventional

Funder types: Other

Identifiers

NCT02442856

821705

Details and patient eligibility

About

The overall objective of this study is to evaluate the use of diffuse correlation spectroscopy to non-invasively measure dynamic cerebral autoregulation in subjects with vascular risk factors. Optical cerebral blood flow measurements will be correlated with changes in arterial blood pressure to assess how CBF is maintained in response to changes in ABP, and will be compared to transcranial doppler reference measurements.

Enrollment: 21 patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age greater than or equal to 50 years
• Positive history of at least one of the following vascular disk factors: hypertension, diabetes, hyperlipidemia, coronary artery disease, atrial fibrillation, prior myocardial infarct, transient ischemic attack, or history of smoking

Exclusion criteria

• Vascular risk factor subjects:

  1. Pregnant women
  2. Prisoners
  3. Prior neurosurgical procedure or traumatic brain injury, including hemicraniectomy or other skull defect
  4. Prior history of ischemic or hemorrhagic stroke
  5. Prior lower extremity amputation
  6. Peripheral vascular disease

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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21 participants in 1 patient group

Intervention

Experimental group

Description:

We will measure dCA with both TCD and DCS during acute changes in mean arterial pressure using thigh cuff deflation techniques in vascular risk factor subjects. Measurements will be compared between TCD and DCS in order to validate DCS as a tool to measure dCA in this population.

Treatment:

Device: Thigh Cuff