Non-invasive Monitoring of Miscarriage

The Chinese University of Hong Kong

Status: Enrolling

Conditions: Miscarriage in First Trimester

Treatments: Other: This is a routine procedure, no intervention will be provided.

Study type: Observational

Funder types: Other

Identifiers

NCT06581692

2024.354

Details and patient eligibility

About

cfDNA is extremely useful to ascertain chromosomal causes of miscarriages at the point of miscarriage diagnosis by a simple blood test. This study aims to determine the level of cell-free DNA (cfDNA) in early pregnancy and compare the results with those of product of conception (POC) testing, in concordance with standard karyotyping.

Full description

Pregnancies achieved by assisted reproductive technologies (ART) are closely monitored, therefore miscarriages that occur very early in the pregnancy are frequently meticulously recorded and reported. On the other hand, spontaneous abortion rates among naturally occurring conceptions are notoriously hard to quantify and are often overstated when using criteria from assisted reproductive technologies. Additionally, women who have undergone treatment with ART are a particular population with traits that can make them more vulnerable to spontaneous abortions.

cfDNA would be extremely useful to ascertain chromosomal causes of miscarriages at the point of miscarriage diagnosis by a simple blood test. This study aims to determine the level of cell-free DNA (cfDNA) in early pregnancy and compare the results with those of product of conception (POC) testing, in concordance with standard karyotyping.

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age 18-45 years.
2. Women who attend the early pregnancy loss clinic or Patients who receive ART
3. Their partner, the biological father of the pregnancy

Exclusion criteria

• History of psychological/ psychiatric problem
• Patient refusal