Non-invasive Neurally Adjusted Ventilatory Assist

Insel Gruppe AG, University Hospital Bern

Status and phase

Withdrawn

Phase 1

Conditions

Respiratory Failure

Treatments

Device: non-invasive neurally adjusted ventilatory assist

Study type

Interventional

Funder types

Other

Identifiers

NCT01280383

BE KEK 123/10

Details and patient eligibility

About

Neurally adjusted ventilatory assist (NAVA) is a new concept of mechanical ventilation. NAVA delivers assistance to spontaneous breathing based on the detection of the electrical activity of the diaphragm. The investigators will study the effects of non-invasive NAVA on respiratory muscle unloading critically ill patients.

Full description

To assess the effects of non-invasive NAVA on respiratory muscle unloading in critically ill patients

Sex

All

Ages

18 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age 18 - 85 years
History of chronic obstructive lung disease
Invasive mechanical ventilation for more than 12 hours
Planned extubation according to the weaning protocol of our clinic
Informed consent obtained from a next of kin
Enrollment approval from a neutral physician neither participating in the study nor in the clinical treatment of the patient

Exclusion criteria

Tracheostomy
Facial or cranial trauma or surgery
Oral, esophageal, diaphragmatic or gastric trauma or surgery
Contraindication to insertion of a nasogastric tube (e. g. malformation, esophageal varices, esophageal perforation or rupture, Zenkers diverticulum, severe bleeding disorder)
Uncooperative state and combativeness not responding to low levels of sedatives
Neurological disease possibly influencing the brainstem respiratory centre, such as but not limited to: intracerebral, subarachnoidal or subdural hemorrhage, cerebral infarction, possible hypoxic encephalopathy
Next of kin refuses informed consent
Pregnancy. In female patients between 18 and 60 years of age, a pregnancy test will be performed.