Non-invasive Neurostimulation as a Tool for Diagnostics and Management for Neurodegenerative Diseases

K

Kuopio University Hospital

Status

Enrolling

Conditions

Alzheimer Disease
Frontotemporal Dementia
Dementia With Lewy Bodies

Treatments

Device: Gamma tACS (40 Hz) over the superior parietal cortex

Study type

Interventional

Funder types

Other

Identifiers

NCT05326750
KUH5772859

Details and patient eligibility

About

Double blinded, sham-controlled, randomized trial on repeated transcranial alternating current brain stimulation (tACS) in neurodegenerative diseases. The investigators will evaluate whether a 4-times daily repeated stimulation with gamma tACS on the posterior parietal cortex can improve symptoms in patients with neurodegenerative diseases, including dementia with Lewy Bodies, Alzheimer's disease, idiopathic normal pressure hydrocephalus and Frontotemporal dementia.

Full description

Double blinded, sham-controlled, randomized trial on repeated transcranial alternating current brain stimulation (tACS) in neurodegenerative diseases. The investigators will evaluate whether a 4-times daily repeated stimulation with gamma tACS on the posterior parietal cortex can improve symptoms in patients with neurodegenerative diseases, including dementia with Lewy Bodies, Alzheimer's disease, idiopathic normal pressure hydrocephalus and Frontotemporal dementia.

Enrollment

200 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Mild Cognitive Impairment due to Alzheimer's disease
  • Dementia with Lewy Bodies
  • Frontotemporal dementia
  • Idiopathic normal pressure hydrocephalus (iNPH)

Exclusion criteria

  • History of seizures
  • Pregnancy
  • Metal implants in the head (except dental fillings)
  • Electronic implants (i.e. pace-maker, implanted medical pump)
  • Age <18 years

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

200 participants in 2 patient groups, including a placebo group

Real tACS
Experimental group
Description:
Four sessions (once a day, during four consecutive days) of gamma tACS (40 Hz) at 3 mA over the superior parietal cortex (Precuneus)
Treatment:
Device: Gamma tACS (40 Hz) over the superior parietal cortex
Sham tACS
Placebo Comparator group
Description:
Four sessions of sham tACS (once a day, during four consecutive days) over the superior parietal cortex (Precuneus)
Treatment:
Device: Gamma tACS (40 Hz) over the superior parietal cortex

Trial contacts and locations

1

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Central trial contact

Eino Solje, MD, PhD

Data sourced from clinicaltrials.gov

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