Non-invasive Placental Chromosome Exploration of Intrauterine Growth Restriction (DPNI-RCIU)

University Hospital of Bordeaux

Status

Enrolling

Conditions

Fetal Growth Retardation

Treatments

Biological: Blood samples

Study type

Observational

Funder types

Other

Identifiers

NCT05023161

CHUBX 2021/12

Details and patient eligibility

About

The objective of this project is the non-invasive prenatal detection of placenta-limited aneuploidies, in patients whose fetuses have a intrauterine growth restriction below 3rd percentile, in parallel with an amniocentesis.

This study will allow the chromosomal study of the placenta in pregnant women whose genetic prenatal diagnosis, made by amniocentesis, does not allow exploring the placental causes of fetal RCIU.

Full description

Placental chromosomal aneuploidies will be detected by high-throughput whole genome sequencing of non-cellular DNA present in maternal plasma during pregnancy.

The study of the cfDNA will be carried out from a blood sample with the automated solution VERISEQ NIPT (Illumina) using the software illumina VeriSeq v2, allowing the detection of all chromosomal abnormalities.

Enrollment

300 estimated patients

Sex

Female

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

over 18 years old,
treated in the DDIANE fetal medicine centre at the Bordeaux University Hospital,
having a fetus with IUGR diagnosis below the 3rd percentile (after reference medical ultrasound),
from 16 weeks of amenorrhea or more,
accepting an Invasive Prenatal Diagnosis by amniocentesis with array comparative genomic hybridization

Exclusion criteria

Childbearing women who: