Non-invasive Prediction of Esophageal Varices in Liver Cirrhosis: A Multicenter Observational Study

General Hospital of Northern Theater Command of Chinese People's Liberation Army

Status: Completed

Conditions: Liver Cirrhosis; Esophageal and Gastric Varices

Treatments: Procedure: Endoscopy

Study type: Observational

Funder types: Other

Identifiers

NCT02593799

NIPEV-1

Details and patient eligibility

About

Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of primary prophylaxis of variceal bleeding.

Full description

Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of primary prophylaxis of variceal bleeding. The investigators' recent systematic review evaluated the diagnostic accuracy of APRI, AAR, FIB-4, FI, King, Lok, Forns, and FibroIndex scores in predicting the presence of esophageal varices in liver cirrhosis. However, their diagnostic accuracy was low to moderate. Further study is warranted to establish a reliable score to predict the presence of high-risk esophageal varice in liver cirrhosis.

Enrollment: 363 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. A diagnosis of liver cirrhosis.
2. Age and sex are not limited.
3. Etiology of liver cirrhosis is not limited.
4. Routine laboratory data.
5. Upper gastrointestinal endoscopy.

Exclusion criteria

1. Non-cirrhotic portal hypertension.
2. Malignancy.
3. Absent laboratory data.
4. A previous diagnosis of esophageal varices.
5. A previous history of variceal bleeding.

Trial design

363 participants in 2 patient groups

Patients with esophageal varices

Description:

Esophageal varices were confirmed by endoscopy. They were divided into "any grade" and "high-risk" varices.

Treatment:

Procedure: Endoscopy

Patients without esophageal varices

Description:

Patients without esophageal varices were divided into patients without "any grade" or "high-risk" varices.

Treatment:

Procedure: Endoscopy