Non-invasive Spinal Cord Stimulation for Spasticity Control and Augmentation of Voluntary Motor Control in Individuals With Multiple Sclerosis (noSpasMS)

Medical University of Vienna

Status and phase: Completed; Early Phase 1

Conditions: Multiple Sclerosis

Treatments: Device: transcutaneous spinal cord stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT04486209

Version MS_tSCS_v1

Details and patient eligibility

About

Epidural spinal cord stimulation (SCS) is currently regarded as one of the most promising intervention methods to improve motor function in individuals with severe spinal cord injury. In parallel, an increasing number of studies is suggesting that noninvasive SCS can improve spasticity and residual motor control in the same subject population. The present study explores whether single sessions of noninvasive SCS would improve walking performance and ameliorate spasticity in individuals with multiple sclerosis.

Enrollment: 15 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• confirmed diagnosis of relapsing-remitting, primary- or secondary-progressive MS
• lower-limb spasticity

Exclusion criteria

• acute relapse of MS
• other neuromuscular diseases
• active and passive implants at vertebral level T9 or caudally
• dermatological issues at stimulation site
• pregnancy

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)