Non Invasive Ventilation During Physical Training in Cystic Fibrosis

K

Karolinska University Hospital

Status

Completed

Conditions

Cystic Fibrosis

Treatments

Device: Non invasive ventilation
Device: Oxygen

Study type

Interventional

Funder types

Other

Identifiers

NCT02684552
2016

Details and patient eligibility

About

Patients with cystic fibrosis older than 18 years will performance a Bruce test with non invasive ventilation (once) after 30 minutes they perform the same test with oxygen supplementation. Measurements: Transcutaneous level off carbon dioxide, saturation, puls and dyspnea scale.

Full description

measurements before and after the test: transcutaneous level off carbon dioxide, saturation, respiratory rate, dyspnea scale.

Enrollment

8 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Subjects with Cystic Fibrosis at Stockholm Cystic Fibrosis center
  • > 18 years of age
  • Forced expiratory volume in one second (FEV1) between 20 and 69% of predicted value
  • Developed alveolar hypoventilation at the physical performance test
  • Use oxygen supplementation during aerobic training

Exclusion criteria

  • Symptomatic upper airway infection characterized by fever less than 1 month before entering the study
  • Cognitive dysfunction
  • Cardio-respiratory instability
  • Infection with Burkholderia cepacia complex
  • Gastroesophageal reflux
  • History of pneumothorax
  • Massive hemoptysis.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

8 participants in 2 patient groups

Non invasive ventilation
Experimental group
Description:
Patients perform physical test with non invasive ventilation
Treatment:
Device: Non invasive ventilation
Oxygen
Active Comparator group
Description:
Patients perform physical test with oxygen with mask
Treatment:
Device: Oxygen

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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