Non-opioid Based Pain Control After Thyroidectomy

MedStar Health

Status: Completed

Conditions: Thyroidectomy; Pain

Treatments: Other: Acetaminophen and ibuprofen based pain control; Other: Acetaminophen and hydrocodone based pain control

Study type: Interventional

Funder types: Other

Identifiers

NCT03988075

2018-022

Details and patient eligibility

About

Pain control modalities were evaluated after thyroidectomy.

Full description

Pain control modalities were evaluated after thyroidectomy. Patients were randomized to one of two pain control regimens. The control group received conventional opioid based post operative analgesia while the test group received an enhanced recovery after surgery (ERAS) based anesthesia with use of acetaminophen and non-steroidal anti-inflammatory drugs for the post operative period with opioid medications available for break through pain only. Pain scores (measured on visual analog scale) and opioid use (measured in morphine equivalent dose) were measured after completion of the operation.

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• thyroid disease

Exclusion criteria

• currently on opioid pain medications
• on opioid pain meds in last 30 days
• cannot take non-opioid medications
• require more extensive operation than thyroidectomy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

100 participants in 2 patient groups

Acetaminophen and hydrocodone based pain control

Active Comparator group

Description:

Patients receive acetaminophen 650mg every 4 for pain level 1-3, hydrocodone/acetaminophen 5/325mg every 4 for pain level 4-6, or hydrocodone/acetaminophen 10/650mg every 4 for pain level 7-10 on as needed basis.

Treatment:

Other: Acetaminophen and hydrocodone based pain control

Acetaminophen and ibuprofen based pain control

Experimental group

Description:

Patients receive standing dose of acetaminophen 650mg every 8 hours and ibuprofen 800mg every 8 hours with alternating ibuprofen and acetaminophen every 4 hours.

Treatment:

Other: Acetaminophen and ibuprofen based pain control