Non-pharmacological Interventions on Cognitive Functions in Older People With Mild Cognitive Impairment

Tzu-Ting Huang

Status: Completed

Conditions: Physical Activity; TTM; Mild Cognitive Impairment; Cognitive Rehabilitation

Treatments: Behavioral: Cognitive training; Behavioral: New life-style; Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03545152

103-7443B

Details and patient eligibility

About

This project is proposed to be a three-year project. The purposes of this project are to develop and examine physical activity program, cognitive rehabilitation training, and new life-style (combination of exercise and cognitive) interventions on primary outcomes (cognitive function), and secondary outcomes (physical fitness, QOL and depression) among community-dwelling elderly adults with MCI.

Full description

Aim. develop and examine physical activity program, cognitive rehabilitation training, and new life-style (combination of exercise and cognitive) interventions on primary outcomes (cognitive function), and secondary outcomes (physical fitness, QOL and depression) among community-dwelling elderly adults with MCI.

Background. Mild cognitive impairment (MCI) is a common clinical syndrome that identifies people at high risk of developing dementia, and the prevalence range from 7.7 to 51.7%. Although treatments for MCI are currently unavailable, preliminary evidence has identified potential neuro-protective effects of exercise program and cognitive rehabilitation, which may lead to improved outcomes. However, the design and delivery of an appropriate program for people with MCI is challenging for having physical, psychological, cognitive, and social barriers.

Design. A prospective randomized control trial. We developed a Physical activity stage-matched intervention (SMI) (1st year), cognitive rehabilitation (2nd year) and New lifestyle program

Enrollment: 192 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• had a subjective memory complaint
• MMSE score<16, 21 or 24, based on their years of education (illiterate, 6 or >9 years, respectively, Yeh et al., 2000), but needed >13 or objective memory impairment: AQ>5 or at least one item of IADL dependence
• able to carry out activities in daily life

Exclusion criteria

• using walking devices
• depression or dementia diagnosis

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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192 participants in 3 patient groups

comparison group

No Intervention group

Description:

No procedure conducted between the pre- and the post-test evaluations, and they received an abridged version of the training after the post-test session.

exercise group

Experimental group

Description:

The exercise program will include instructions on how to read the program, complete the activities, record their sessions, and exercise safely at first day. To promote incorporating exercising in their daily life routine during the 24-week period, we provided 2 group-based (5-8 participants with 2 instructors at community centers, 60' each) and one home-based (with the exercise program VCD and manual to bring home, 30') exercise program.

Treatment:

Behavioral: Exercise

Behavioral: New life-style

cognitive training group

Experimental group

Description:

Consisted of 12 weekly sessions, lasting 60-90 minutes in groups of 5-8 participants, and 3 monthly boost sessions (to review the strategies and practice solving problems as well). The main strategy was to use cognitive rehabilitation strategies to promote generalization in this process to improve memory and behavior.

Treatment:

Behavioral: Cognitive training

Behavioral: New life-style