Non-small Cell Lung Cancer With Central Nervous System Metastasis

National Taiwan University

Status: Enrolling

Conditions: Lung Cancer With Central Nervous System Metastasis

Treatments: Other: lung cancer with brain /leptomeningeal metastasis

Study type: Observational

Funder types: Other

Identifiers

NCT06026735

202209032RINB

Details and patient eligibility

About

Cerebrospinal fluid was obtained from the cerebrospinal cavity of non-small cell lung cancer patients with central nervous system metastasis, blood was obtained from veins, and metastatic lung cancer tumor tissue was obtained from surgically resected brain tumors or meningeal tumors. Then comprehensively analyze the exosomes contained in the aforementioned samples, and compare and analyze the clinical data of the patients, so as to explore whether the cancer cell-related substances contained in the cerebrospinal fluid, blood and tumor tissue can be used to predict lung cancer metastasis and Bioindicators of treatment effect.

Enrollment: 30 estimated patients

Sex: All

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• A. Non-small cell lung cancer patients diagnosed with brain metastases or meningeal metastases on brain computed tomography (CT) or magnetic resonance (MRI) images.

B. Patients with non-small cell lung cancer who are about to undergo surgical brain surgery, such as brain tumor resection, lumbar abdominal drainage, Euclidean storage, or ventriculoperitoneal drainage.

Exclusion criteria

• A. Non-small cell lung cancer patients without brain metastases or meningeal metastases.

B. Physical condition does not allow surgical removal of the tumor.

Trial design

30 participants in 2 patient groups

lung cancer with brain metastasis

Treatment:

Other: lung cancer with brain /leptomeningeal metastasis

lung cancer with leptomeningeal metastasis

Treatment:

Other: lung cancer with brain /leptomeningeal metastasis