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Non-surgical Interventions for Infertility in Endometriosis (RCT)

B

Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Status and phase

Completed
Phase 2

Conditions

Endometriosis
Infertility, Female

Treatments

Drug: Cabergoline plus timed intercourse
Drug: Dydrogesterone plus timed intercourse

Study type

Interventional

Funder types

Other

Identifiers

NCT06560814
BSMMU/2021/06

Details and patient eligibility

About

A parallel design randomized clinical trial was carried out on 18 women with clinically diagnosed endometriosis who wish pregnancy in the Department of Reproductive Endocrinology and Infertility, Bangabandhu Sheikh Mujib Medical University, (BSMMU), Shahbag, Dhaka. Those who voluntarily provide consent to participate in this study will be randomly allocated to one of the two treatment arms. Allocation concealment will be done by sequentially numbered sealed envelopes. The arms and interventions are cabergoline (0.5 mg twice weekly for 6 months, plus timed intercourse) and dydrogesteron (20 mg daily from day 5 to day 25 of menstrual cycle for 6 months, plus timed intercourse).The women will be assessed by telephone interview at monthly intervals, TVS and serum Ca 125 at 3 months and 6 months.

Full description

Infertile women with endometriosis will be recruited from those attending Dept of Reproductive Endocrinology and Infertility after clinical diagnosis on the basis of sonographic findings of chocolate cyst with or without dysmenorrhea. After evaluating for eligibility criteria and taking informed consent she will be randomized to either cabergoline group or to dydrogesterone group. Women assigned to cabergoline group will receive 0.5 mg cabergoline twice weekly (fridays and tuesdays), after meal at night for 6 months. The dydrogesterone group will receive 10 mg of dydrogesterone twice daily from day 5 to day 25 of menstrual cycle for six months. She will be followed up every month to check for compliance or any side effects. The couple will have intercourse timed with LH kit or intercourse on alternate days from day 10 to day 15 of the cycle if the LH kit is not available. She will visit 3 months and 6 months after the beginning of treatment. At each follow up visit, she will be assessed for pregnancy, visual analog scale for pain and transvaginal sonogram to measure the chocolate cyst. Estimation of serum CA125 and any side effects will be noted.

Enrollment

18 patients

Sex

Female

Ages

18 to 35 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Women of reproductive age 18-35 yrs
  2. Women who are infertile or wish pregnancy
  3. Sonographic diagnosis of chocolate cyst with or without dysmenorrhea
  4. Women staying with her husband

Exclusion criteria

  1. Recurrent endometrioma after previous surgery
  2. BMI at or more than 30 kg/m2
  3. Significant abnormalities in renal and liver function.
  4. Known male factor
  5. Use of investigational drugs or hormones, concomitant or in last 30 days.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

18 participants in 2 patient groups

Cabergoline
Experimental group
Description:
Tab Cabergoline 0.5 mg twice weekly for 24 weeks, plus timed intercourse
Treatment:
Drug: Cabergoline plus timed intercourse
Dydrogesterone
Active Comparator group
Description:
tab Dydrogesterone( 10 mg) twice daily from day 5 to day 25 of menstrual cycle for 24 weeks, plus timed intercourse
Treatment:
Drug: Dydrogesterone plus timed intercourse

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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