Non-surgical Peridontal Treatment on Cardiovascular Risk Markers

Kırıkkale University

Status: Completed

Conditions: Chronic Periodontitis; Cardiovascular Risk Markers

Treatments: Other: Non-surgical periodontal treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT04540328

2015 / 029

Details and patient eligibility

About

The study evaluates the influence of non-surgical mechanical periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases

Full description

A total of 80 non-smokers with systemically healthy, including 40 patients with severe chronic periodontitis and 40 periodontally health subjects were included into the present study. The probing depth, clinical attachment level, plaque index, gingival index and blood samples were collected at baseline and at the 3rd months after treatment and the serum levels of asymmetric dimethylarginine (ADMA), endothelial nitric oxide synthase (eNOS), homocysteine (Hcy), monocyte chemoattractant protein-1 (MCP-1) were determined with enzyme-linked immunosorbent assay (ELISA).

Enrollment: 80 patients

Sex: All

Ages: 30 to 54 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Clinical diagnosis of severe chronic periodontitis

Clinical diagnosis of periodontal health

Exclusion criteria

Systemic diseases such as diabetes, cardiovascular disease

Periodontal treatment within the previous year

Drugs such as systemic steroids, non-steroidal anti-inflammatory drugs, immunosuppressants, hormone drugs, contraceptives, anticoagulants, cholesterol regulating drugs, systemic antibiotics, antioxidants within the previous 3 months

Pregnant or lactating

Consumed alcohol

Smoker

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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80 participants in 1 patient group

Non-surgical peridontal treatment

Other group

Description:

Patients with chronic periodontitis received non-surgical periodontal treatment, including scaling and root planing and polishing within 14 days under local anesthesia with manual and ultrasonic devices and standardized oral hygiene instructions including methods of tooth-brushing and interdental cleaning were also given to each one. A professional supragingival plaque control was applied on a regular basis every month.

Treatment:

Other: Non-surgical periodontal treatment