Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: the Correlation Analysis and Risk Prediction Model Study

Wuhan University

Status: Unknown

Conditions: Cardiovascular Diseases; NAFLD

Study type: Observational

Funder types: Other

Identifiers

NCT03534908

WDRY2017-K009

Details and patient eligibility

About

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the world. NAFLD is associated with a lot of comorbidity, such as diabetes, metabolic syndrome, coronary heart disease and chronic kidney diseases. However, the correlation between the NAFLD and cardiovascular disease (CVD) events remains controversial. This study is an observational study based on a big retrospective cohort in china to explore the prevalence of NAFLD in China, the risk factors associated with NAFLD, as well as whether patients with NAFLD are more prone to experience CVDs and CVD events.

Enrollment: 5,000,000 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• males or females aged 18-75

Exclusion criteria

• malignancy except primary liver cancer
• pregnancy or breastfeeding
• liver diseases of other etiology including hepatitis C virus infection ,autoimmune hepatitis,Wilson's disease,hemachromatosis,drug-induced hepatitis,parenteral nutrition
• excessive alcohol consumption
• cases missing crucial data

Trial design

5,000,000 participants in 2 patient groups

NAFLD group

Description:

those with NAFLD

Control group

Description:

those without NAFLD