Noninvasive Intratumor Heterogeneity Evaluation in HNSCC

Chongqing Medical University

Status: Enrolling

Conditions: Head and Neck Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT07027280

xChen

Details and patient eligibility

About

This study focuses on tumor heterogeneity, a core challenge in the field of oncology, and innovatively utilizes patient imaging data to deeply mine and analyze intratumoral heterogeneity. By constructing an imaging analysis model for tumor heterogeneity and associating this model with clinical, pathological, transcriptomic, and metabolomic data of patients, a multi-omics decoding of tumor heterogeneity is achieved. The main questions it aims to address are:

Can the ITH model stratify patients' treatment efficacy and prognosis assessment? Can pathological and multi-omics sequencing map the mechanisms behind the ITH model?

Enrollment: 700 estimated patients

Sex: All

Ages: 15 to 89 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Pathologically confirmed head and neck squamous cell carcinoma (HNSCC). Complete clinical, imaging, and pathological data. Available complete follow-up information.

Exclusion criteria

Patients who received chemotherapy or radiotherapy before surgery. Poor image quality. Tumors too small to be easily identified. History of other concurrent malignant tumors.

Trial design

700 participants in 3 patient groups

Training set

Test set

Pathological set