Noninvasive Positive Pressure Ventilation in Overlap Syndrome

Chinese Academy of Medical Sciences, Fuwai Hospital

Status: Unknown

Conditions: Sleep Apnea Syndromes; Non-invasive Positive Pressure Ventilation; COPD

Treatments: Device: NIPPV

Study type: Interventional

Funder types: Other

Identifiers

NCT03184714

2016YFC1304403B

Details and patient eligibility

About

Chronic obstructive pulmonary diseases (COPD) coexisting with obstructive sleep apnea is called overlap syndrome (OS). Patients with OS seem to have worse prognosis than patients with only one disorder. Noninvasive positive pressure ventilation is an efficient treatment in obstructive sleep apnea, but the effectiveness in improving outcomes of OS patients is still not fully investigated. The aim of this non-randomized concurrent control trial is to evaluate noninvasive positive pressure ventilation's effectiveness in OS patients.

Enrollment: 292 estimated patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with COPD and sleep apnea dyspnea syndrome

Exclusion criteria

• patients with non-stable hemodynamics;
• patients with limited life expectancy;
• patients with other severe respiratory diseases;
• patients with motor neuron diseases;
• patients with contraindications for NIPPV

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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292 participants in 2 patient groups

Control

No Intervention group

Interventional group

Experimental group

Description:

NIPPV as treatment of OS

Treatment:

Device: NIPPV