Noninvasive Positive Pressure Ventilation Using Helium:Oxygen Versus Air:Oxygen in Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease Patients Exposed to Sulfur Mustard

Baqiyatallah Medical Sciences University

Status and phase: Completed; Phase 3

Conditions: Bronchiolitis; Chronic Obstructive Pulmonary Disease

Treatments: Drug: helium:oxygen

Study type: Interventional

Funder types: Other

Identifiers

NCT00515606

210586

Details and patient eligibility

About

to assess the effectiveness of helium:oxygen mixture adjunct with non-invasive ventilation in sulfur mustard exposed patients with acute decompensation

Sex: Male

Ages: 38 to 59 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• a history of previous exposure to sulfur mustard
• worsening dyspnea during the last 10 days
• respiratory rate >25/min
• arterial pH<7.35
• PaCO2 of >50 mmHg
• PaO2 of <50 mmHg

Exclusion criteria

• recent pneumothorax (<1 month)
• severe respiratory failure or hemodynamic instability with forthcoming intubation
• FIO2 of <0.4
• impaired consciousness or absence of patient cooperation
• facial lesions precluding NIV

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind