Noninvasive Real-Time Arterial Waveform Monitoring for Cardiovascular Disease Assessment

Anhui Provincial Cancer Hospital

Status: Enrolling

Conditions: Aortic Regurgitation Disease; Healthy Subjects; Aortic Stenosis Disease

Study type: Observational

Funder types: Other

Identifiers

NCT07350629

2025-APW-001

Details and patient eligibility

About

The goal of this observational study is to learn whether noninvasive real-time arterial waveform monitoring can be used to assess cardiovascular diseases in adults. The main question it aims to answer is:

Can photoacoustic imaging accurately capture arterial waveforms from patients' fingers? Can features extracted from the arterial waveforms reflect the type and severity of cardiovascular diseases? Participants will be asked to place their fingers into the imaging device, where their finger arterial pulse information will be noninvasively recorded.

Enrollment: 15 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-80 years
• Able to provide informed consent
• For AR group: clinically diagnosed aortic regurgitation
• For AS group: clinically diagnosed aortic stenosis
• For healthy controls: no history of cardiovascular disease
• Able to undergo finger arterial waveform measurement

Exclusion criteria

• History of recent cardiac surgery or intervention (<6 months)
• Hand disorders affecting finger mobility (e.g., arthritis)
• Pregnant or breastfeeding women
• Participation in other studies affecting arterial waveform
• Unable to understand or comply with study procedures

Trial design

15 participants in 3 patient groups

Healthy Subjects

Description:

Healthy adult volunteers with no known cardiovascular disease will undergo noninvasive arterial waveform acquisition using the photoacoustic imaging device. No intervention is applied; data collection provides baseline waveform features for comparison with AR and AS patients.

Aortic Regurgitation (AR) Patients

Description:

Participants diagnosed with aortic regurgitation (AR) will undergo noninvasive arterial waveform acquisition using a photoacoustic imaging device. No intervention is applied; data collection focuses on capturing finger arterial pulse waveforms to assess features associated with AR.

Aortic Stenosis (AS) Patients

Description:

Participants diagnosed with aortic stenosis (AS) will undergo noninvasive arterial waveform acquisition using the same photoacoustic imaging device. No intervention is applied; data collection focuses on capturing finger arterial pulse waveforms to assess features associated with AS.