Noninvasive Surrogate Marker for Advanced Hepatocellular Carcinoma Response to Concurrent Chemoradiotherapy: MR Perfusion, Contrast Enhanced Ultrasound and Biomarkers

Yonsei University

Status

Unknown

Conditions

Advanced Adult Hepatocellular Carcinoma

Treatments

Radiation: DCE MRI

Study type

Interventional

Funder types

Other

Identifiers

NCT01336452

4-2010-0566

Details and patient eligibility

About

Hepatocellular carcinoma is the sixth most common malignancy and the third most common cause of cancer-related death worldwide. The incidence of HCC is rising in Europe and the United States and is expected to continue to increase during the next 2 to 3 decades. The expected survival rate is still decimal, especially in patients with advanced HCC. However, in recent years, several treatment methods for patients with advanced HCC, including antiangiogenic chemotherapy, radiotherapy, concurrent chemoradiotherapy, and DC bead transarterial chemoembolization, have been developed. Among these new treatment methods, concurrent chemoradiotherapy has also proved to increase patient's survival rate. It is important to predict treatment response before treatment or immediately after treatment because there are several other treatment options as mentioned above. Recently, there have been several reports that MR perfusion parameters such as Ktrans can predict treatment response in cervical cancer and colorectal cancer. Therefore the purpose of the investigators study is to evaluate the feasibility of predicting treatment response by MR perfusion, contrast enhanced ultrasound parameters and biomarkers (IL-6, IL-12 and VEGF) in patients with advanced hepatocellular carcinoma who undertake concurrent chemoradiotherapy.

Enrollment

30 estimated patients

Sex

All

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients who have advanced hepatocellular carcinoma and plan to undertake concurrent chemoradiotherapy.
Patients willing to undergo the study procedure
Patients who are fully informed about the study and have signed the informed consent form

Exclusion criteria

Patients (men or women) under 20 years of age
Patients who have been received any other treatment including TACE, operation, TACI, systemic chemotherapy, intraarterial chemotherapy, antiangiogenic therapy
Patients who have hypersensitivity to MR or US contrast agents
Women who are pregnant, lactating or who are of childbearing potential and have not had a negative pregnancy test at baseline visit
Patients not eligible to contrast media injection according to product labeling
Patients with a contraindication for MRI or CT
Patients with impaired renal function (e.g. acute renal failure) or patients on dialysis