Noninvasive Ventilation on Chronic Obstructive Pulmonary Disease (COPD) Patient Functionality (kmarrara)

Universidade Federal de Sao Carlos

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Treatments: Other: physical training

Study type: Interventional

Funder types: Other

Identifiers

NCT01464736

UFSCar

Details and patient eligibility

About

On the following tests, there would be a greater increase in the functionality of COPD patients who underwent combined therapy than in those who only exercised: a set of activities of daily living (ADLs), the six-minute walk test (6MWT), an incremental symptom-limited cardiopulmonary test (CPT), and the physical functioning scale of the Short-Form 36 quality of life questionnaire (SF-36).

Full description

Impact of aerobic exercise plus noninvasive ventilation (NIV) on the functionality of patients with COPD. Thirty patients (70.5 - 8.5 years) with COPD (forced expiratory volume in the first second 48.5 - 15.4% of predicted) were randomized into either a physical training group involving aerobic treadmill exercise (PTG, n=12) or an exercise plus bilevel ventilation group (PTGNIV, n=11) with sessions three times a week for six weeks.

Enrollment: 23 patients

Sex: Male

Ages: 60 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COPD diagnosis
• with a forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC)<70%
• clinical stability in the previous two months (i.e., no exacerbation of the disease).

Exclusion criteria

• decompensated heart failure or rheumatic, orthopedic or neuromuscular diseases that prevented the subjects from performing the tests due to exercise limitations;
• participation in a regular physical exercise program at the beginning of the study;
• noncompletion of one of the tests or the established protocol for any reason.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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23 participants in 2 patient groups

Physical Training Group

Experimental group

Description:

This group performed aerobic physical training in treadmill.

Treatment:

Other: physical training

NIV Trained

Experimental group

Description:

This group performed aerobic physical training associated with ventilation in the bilevel modality (BiPAP®), using a nasal mask as an interface. On evaluation day, the levels of inspiratory positive airway pressure (IPAP) (between 10 and 15cmH2O) and expiratory positive airway pressure (EPAP) (between 4 and 6cmH2O) were defined, varying according to the comfort level of each patient.

Treatment:

Other: physical training