Noninvasive Ventilation Therapy for the Treatment of Pleural Effusion in Patients With Heart Failure

Heart and Diabetes Center North-Rhine Westfalia

Status

Completed

Conditions

Pleural Effusion

Heart Failure

Treatments

Device: Non-invasive ventilation

Study type

Observational

Funder types

Other

Identifiers

NCT03189654

HDZNRW-KA_010_TB

Details and patient eligibility

About

There are no investigations so far whether an application of positive pressure during non-invasive ventilation might be a therapeutic option for transudative pleural effusion in patients with heart failure. In view of the pathophysiological process with pleural effusion resulting from an increase in intravascular hydrostatic pressure, non-invasive ventilation might provide an improvement.

The aim of the present study is to investigate whether an additional non-invasive ventilation therapy leads to an improved suppression of pleural effusion in heart failure patients.

Enrollment

11 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients admitted to our hospital on a routine or emergency basis
Patients with heart failure according to the current ESC guidelines and chronic pleural effusion with clinical indication for pleurocentesis
Non-invasively determined cardiac index of < 2.5 l/min/m²
BNP > 300 pg/ml
Transudative pleural effusion according to Light criteria
Effective pleurocentesis with residual effusion on the side affected of < 500 ml
Tolerance of non-invasive ventilation without subjective or objective hemodynamic impairment as verified during a test ventilation
No change in drug or other therapy for the duration of the study (5 days)

Exclusion criteria

Psychological or neurological concomitant disease making an informed consent impossible
Pregnancy
Pneumothorax or pneumomediastinum
Pathologically low blood pressure, particularly associated with intravascular volume depletion
Liquor discharge, recent head surgery or trauma
Severe bullous lung disease
Dehydration
Current ventilation therapy
Bilateral pleural effusion > 500 ml at the time of enrolment
Exudative pleural effusion