Noradrenaline Infusion Versus Phenylephrine Infusion in Improving Serum Lactate Level in HIPEC

Suez Canal University

Status: Completed

Conditions: Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

Treatments: Drug: NORADRENALIN; Drug: PHENYLEPHRINE

Study type: Interventional

Funder types: Other

Identifiers

NCT04144465

noradrenaline vs phenylephrine

Details and patient eligibility

About

ABG PARAMETERS ARE CHANGED DURING HIPEC, WE TRIED TO FIND COMPARISON BETWEEN NORADRENALINE AND PHENYLEPHRINE IN OPTIMIZING ABG PARAMETERS THAT REFLECTS ORGAN PERFUSIONS ESPECIALLY SERUM LACTATE

Full description

Arterial blood gas testing is considered one of the most important and widely used test in the detection of acidosis, alkalosis, electrolytes disturbance and tissue perfusion. in regard to tissue perfusion serum lactate above 4 mmol/L indicates poor tissue perfusion. serum lactate could be measured at ABG or separately. in this study we will test the effect of both noradrenaline and phenylephrine on lactate level at ABG during the stage of HIPAC in managing abdominal cancer patients.

Enrollment: 30 patients

Sex: All

Ages: 35+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• CANCER PATIENTS ENROLLED FOR HIPEC

Exclusion criteria

• DRUG SENSITIVITY

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups

NORADRENALIN

Active Comparator group

Description:

NORADRENALINE INFUSION

Treatment:

Drug: NORADRENALIN

PHENYLEPHRINE

Active Comparator group

Description:

PHENYLEPHRINE INFUSION

Treatment:

Drug: PHENYLEPHRINE