Norepinephrine as Early Vasopressor Therapy in Children Undergoing Mechanical Ventilation

Unidade de Terapia Intensiva

Status and phase: Unknown; Phase 4

Conditions: Shock; Mechanical Ventilation

Treatments: Drug: Placebo; Drug: Norepinephrine

Study type: Interventional

Funder types: Other

Identifiers

NCT00894621

Noradrenalina precoce em UTIP

Details and patient eligibility

About

The purpose of this study is to assess the effectiveness from early infusion of norepinephrine in pediatric patients submitted to mechanical ventilation for the use of sedative and analgesics drugs.

Enrollment: 40 patients

Sex: All

Ages: 1 month to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children, who, in the arrival or during the admission in pediatric intensive care unit, develop the need for mechanical ventilation and continuous infusion of sedatives and/or analgesics

Exclusion criteria

• Patients after cardiac arrest
• Patients with tracheostomy
• Patients with renal and/or hepatic failure
• Patients with previous episode of cardiac arrythmia
• Patients with mechanical ventilation forecast lesser that four days

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

40 participants in 2 patient groups, including a placebo group

Norepinephrine

Experimental group

Treatment:

Drug: Norepinephrine

Placebo

Placebo Comparator group

Treatment:

Drug: Placebo