Norepinephrine Weaning in Septic Patients (CATECHOFLOU)

Association pour le Développement de la Recherche et de l'Enseignement en Médecine d'Urgence

Status and phase: Completed; Phase 4

Conditions: Septic Shock

Treatments: Device: norepinephrine infused under computerized fuzzy logic control; Device: norepinephrine infused at the clinician's discretion

Study type: Interventional

Funder types: Other

Identifiers

NCT00763906

DH/JF-11-2002

Details and patient eligibility

About

The weaning rate of vasopressors drugs is usually chosen empirically by the clinician in critically patients. The investigators applied fuzzy logic principles to modify intravenous norepinephrine infusion rates during norepinephrine infusion in septic patients in order to reduce the duration of shock. The investigators goal was to reduce the duration of poorly controlled hemodynamic status.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Septic shock

Exclusion criteria

• Less than 18 years
• Pregnancy
• Weight above 135 kg
• Requirement for continuous epinephrine infusion
• Severe head injury, stroke, a comatose state following cardiac arrest

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups, including a placebo group

1

Placebo Comparator group

Description:

Patients were assigned to norepinephrine infused at the clinician's discretion.

Treatment:

Device: norepinephrine infused at the clinician's discretion

2

Active Comparator group

Description:

Patients were assigned to norepinephrine infused under computerized fuzzy logic control.

Treatment:

Device: norepinephrine infused under computerized fuzzy logic control