Normal Saline Versus Heparin Intermittent Flushing for the Prevention of Occlusion in Port-a-Cath

Chang Gung Medical Foundation

Status: Not yet enrolling

Conditions: Port-a-cath Occlusion; Normal Saline; Heparin Lock

Treatments: Drug: Normal Saline Flush 20 ml; Drug: Heparin Flush (1000 USP, 10ml); Drug: Normal Saline Flush 10 ml

Study type: Interventional

Funder types: Other

Identifiers

NCT05707936

CMRPVVM0141

Details and patient eligibility

About

Purpose:

An evidence implementation of a randomized controlled trial for whether there is the difference in intermittent flushing 0.9% normal saline and heparin? Design: a single-blind randomized controlled trial

Method:

This study is based on the 5A (Ask, Acquire, Appraise, Apply, Audit) of evidence health care step, and design randomized controlled trial for evidence implementation.

We will include inpatients over 20 years-old adults in New Taipei City TuCheng Hospital, Taiwan, who need administration medicine by port-a-catcher. The sample size is 192 according to G-power software. Random allocation software has using for block randomization, would assign to group A: flushing with 0.9% normal saline 10ml, group B: flushing with 0.9% normal saline 20ml, and group C: flushing with heparin 100 USP/ml. SPSS 20.0 software for statistical analysis, mean or standard deviation, one- way ANOVA would use.

Enrollment: 192 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Non-pediatric inpatients over 20 years of age with PAC placed for any disease and who need medication during hospitalization.

Exclusion criteria

History of PAC obstruction, continuous high volume drip via PAC, taking anticoagulant or antiplatelet agents, abnormal blood coagulation, pregnancy or contraceptive use, specified flushing solution by case

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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192 participants in 3 patient groups

Normal saline 20 ml

Experimental group

Treatment:

Drug: Normal Saline Flush 20 ml

Normal saline 10 ml

Experimental group

Treatment:

Drug: Normal Saline Flush 10 ml

usual care (heparin)

Active Comparator group

Treatment:

Drug: Heparin Flush (1000 USP, 10ml)