Normal Values for Esophageal High Resolution Manometry in an Advanced Protocol Including Liquid Swallows and a Solid Test Meal (Rice)
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About
Normal values for measurements of high resolution manometry in a protocol which includes isolated liquid swallows in upright and recumbent position, free drinking of water, a solid test meal and a postprandial observational period will be determined.
Full description
The investigators will recruit healthy volunteers and ask for study participation. After providing informed consent, participants will be questioned using standardized questionnaires assessing symptoms of reflux, dysphagia, gastrointestinal symptom burden and depression. Participants will be tested using our advanced protocol for high resolution esophageal manometry. This protocol includes individual liquid swallows, free drinking of water, a standardized test meal (200g rice) and a postprandial observational period. Normal values for liquid and solid swallows will be determined.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Healthy volunteers without gastrointestinal co-morbidity
Exclusion criteria
- Inability or unwillingness to provide informed consent
- Any relevant current or past gastrointestinal morbidity (including diseases relevant previous surgery).
- Relevant gastrointestinal symptoms
- Relevant medication (as specified below) within the last 4 weeks
- Age below 18 years
Trial design
Primary purpose
Allocation
Interventional model
Masking
73 participants in 1 patient group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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