Normal Ventilatory and Perfusion Pulmonary Function in TEMP (3DSPECSTAT)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Patents With Normal VQ/SPECT

Study type: Observational

Funder types: Other

Identifiers

NCT04332406

29BRC19.0129

Details and patient eligibility

About

Ventilation - perfusion SPECT is attractive for lung function assessement. Unfortunately, it is very difficult to delineate normal to abnormal areas because of physiological uptake heterogeneity.

In that context, it would be of interest to build statistical maps from registrered normal studies and propose a new methodology for normal SPECT delineation

Full description

Patients with normal VQ SPECT-CT will be analysed. After a image proccesing workflow including rigid registration, non rigid registration and normalization, a voxelized mean and standard deviation map will be created. Those maps will be analyzed in regards of physiology and litterature.

Enrollment: 96 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• normal perfusion and ventilation scans, and no parenchyma or pleural abnormality on low dose CT
• confirmation by a second senior physician

Exclusion criteria

Patients with history of pulmonary disease:

• chronic obstruction pulmonary disease,
• previous pulmonary embolism,
• surgery of the lungs
• radiotherapy of the lungs