Normative Dynamic & Magnetic Spine (NDMS)

Centre d'Investigation Clinique et Technologique 805

Status

Terminated

Conditions

Healthy Volunteers

Dynamic Stability Margin

Paraspinal Muscles

Gait

Treatments

Other: EOS full-spine, MRI, gait analysis

Study type

Interventional

Funder types

Other

Identifiers

NCT03125434

2016-A01825-46

Details and patient eligibility

About

This study aims to describe normal spinal musculoskeletal patterns in healthy adolescents and young adults by using static and dynamic measures. Static informations are obtained from full-spine stereoradiography for skeletal measures and from high-resolution spine muscle MRI for muscular data. Dynamics stability is calculated from 3D gait analysis.

Full description

Spinal diseases and deformities in adults (degenerative or traumatic) and children (scoliosis and kyphosis) are major public health issues.

Postural imbalance due to spinal deformity is usually measured on static radiographs, using standard X-rays. However, bipedal walk is characteristic from human being and the trunk is the main stabilizer.

Pathogenesis of spinal deformities remains undefined. To understand the different mechanisms involved in the pathological field, normal musculoskeletal performances of the spine, in static and dynamic conditions must be identified.

Ultra-low doses stereoradiography using the EOS system allows the acquisition of full-spine images in standing position. Furthermore, 3D reconstruction can also be create from both anteroom-posterior and lateral side view. Stereoradiography is used in clinical routine especially in children spinal deformities.

High resolution muscular MRI is the only device that can provide a detailed muscular analysis, with detection of abnormalities at an early stage. No mapping of normal paraspinal muscles has been yet realized, particularly regarding to rotatores muscles.

Motion analysis is the reference exam to analyse dynamic stability during gait. Several parameters reflecting stability during gait can be collected in different conditions. Recently, the "Dynamic Stability Margin" has been developed but no standard values especially in healthy children has been published.

Enrollment

48 patients

Sex

All

Ages

8 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Informed consent signed by adult or by the holders of parental authority for the children and adolescents
Child or teenager, male or female, aged from 8 years to 17 years inclusive
Adult, male or female, aged from 18 years to 40 years inclusive
Realization of a preliminary medical examination

Exclusion criteria

Refuse to participate to the study
Patient under guardianship or curatorship
Inability to cooperate
Pregnant woman
Non affiliation to social security
Subject with spinal and/or lower limbs affection
Subject with antecedent of spinal and/or lower limbs surgery
Subject with contraindication to MRI
Refusal of the parent or the subject to be informed about a fortuitous discovery during the examinations of the exams