Normative Values Laser Nociceptive Evoked Potentials Depending on the Age

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Healthy

Treatments: Device: laser stimulations on face and neck; Device: laser stimulations cervical; Device: laser stimulations on lower limbs; Device: 20 laser stimulations for each site on the upper limbs

Study type: Interventional

Funder types: Other

Identifiers

NCT02531048

2007- A00535-48 (Other Identifier)

0701035

Details and patient eligibility

About

Different neurological damage may alter the pain conduction systems centrally (spinothalamic pathway) or peripherally (small caliber sensory fibers A delta and C). The laser thermal stimulation selectively stimulates the pain pathways and generates nociceptive signals conveyed to the cortex. Registering these cortical responses constitute the technical laser nociceptive evoked potentials. If these tests are routinely used, their interpretation must remain cautious especially in the elderly.

Full description

Different neurological damage may alter the pain conduction systems centrally (spinothalamic pathway) or peripherally (small caliber sensory fibers A delta and C). The laser thermal stimulation selectively stimulates the pain pathways and generates nociceptive signals conveyed to the cortex. Registering these cortical responses constitute the technical laser nociceptive evoked potentials. If these tests are routinely used, their interpretation must remain cautious especially in the elderly. Normal values that are available have been obtained in young subjects. However, various studies have shown that the integration of nociceptive messages depended on age. The aim of this study was to establish normal values of nociceptive evoked potentials for each age group of 18 to 75 years.

Enrollment: 120 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• major

Exclusion criteria

• Neurological history
• Neuralgia history (> 3 months)
• Pathology can cause neuropathy (unbalanced thyroid dysfunction, diabetes, kidney failure, chronic hepatitis, HIV ...)
• Dermatological disorder known type of Lucite or photosensitivity
• Medical treatment analgesic, psychotropic or anti-epileptic underway
• Toxic acquired in the last 72 hours (alcohol, cannabis, other toxic ...)
• Pregnant women
• Incapacitate to stand still
• Participation in another biomedical research in the field of pain in the three months prior to inclusion.

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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120 participants in 1 patient group

healthy volunteers

Experimental group

Description:

Healthy volunteers are able to participate to this study. They must not have neurological troubles. They will have different stimulations : * laser stimulations on lower limbs * laser stimulations cervical * 20 laser stimulations for each site on the upper limbs * laser stimulations on face and neck

Treatment:

Device: laser stimulations on face and neck

Device: 20 laser stimulations for each site on the upper limbs

Device: laser stimulations cervical

Device: laser stimulations on lower limbs