Novel Approach for Embryo Transfer Medium by Adding Cytokine to Hyaluronan Enriched Embryo Transfer Medium (Embryo Glue)

Ibn Sina Hospital

Status: Completed

Conditions: Infertility

Treatments: Other: Cytokine group

Study type: Interventional

Funder types: Other

Identifiers

NCT02422134

Ibnsina IVF Sohag

Details and patient eligibility

About

It was proven that the Cytokine granulocyte-Macrophage clony stimulating factor had been found naturally in reproductive tract so our target is to test its effect if added to embryo transfer medium.

Full description

The IVF embryo transfer media design and upgrade underwent many ideas during the last 3 decades, we suppose that adding Cytokine GM-CSF as an endometrial modifier to already proven successful medium hyaluronan enriched medium to test the efficacy ipon pregnancy and implantation rate in vitro so we decide to design a trial to compare the clinical outcome by sibling embryo to be transferred into 2 groups and the same culture condition but with one arm with Cytokine and the other is traditional one and closely monitor the outcome within the 2 arms and record the results.

Enrollment: 400 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• all patients

Exclusion criteria

• above 40 years old

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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400 participants in 2 patient groups

Cytokine plus Hyalurinan embryo transfer arm

Active Comparator group

Description:

To monitor the pregnancy and implantation of the patients in this arm after adding Cytokine to the embryo transfer medium.

Treatment:

Other: Cytokine group

Hyalurinan embryo transfer group

No Intervention group

Description:

To transfer the embryos using a Hyaluronan enriched medium only