Novel BIochemical Markers for Predicting Type 2 NEurological Complications of Surgical Coronary Revascularization (BINER)

Collegium Medicum w Bydgoszczy

Status

Completed

Conditions

Neurological Complication of Procedure (Disorder)

Treatments

Other: exposure to type 2 neurological complications

Study type

Observational

Funder types

Other

Identifiers

NCT03493256

KB 776/2017

Details and patient eligibility

About

In this single center prospective cohort study a total of 100 patients scheduled for elective off-pump CABG will be recruited. They will be allocated to one study and one control group according to the presence or absence of postoperative type 2 neurological complications. The two groups will be compared in terms of serum concentrations of glial fibrillary acidic protein (GFAP), neuroserpin (NSP), phosphorylated axonal neurofilament subunit H (pNfH) and visinin-like protein 1 (VILIP-1) at the time of skin incision and closure as well as 24 hours and 7 days following surgery. Diagnostic performance of these markers for predicting type 2 neurological complications of off-pump CABG will be assessed.

Enrollment

100 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

patients scheduled for elective off-pump Coronary Artery Bypass Grafting (CABG)

Exclusion criteria

neurological or psychiatric disorders
alcohol or drug abuse
preoperative left ventricular ejection fraction of less than 30%
extracranial carotid artery stenosis of more than 70%
scoring below age- and education-adjusted cut-off values in Mini-Mental State Examination (MMSE)
scoring over seven points on the subscales of the Hospital Anxiety and Depression Scale (HADS)