Novel Biomarkers and Postoperative Kidney Injury in Radical Nephrectomy

Peking University

Status: Enrolling

Conditions: Acute Kidney Injury; Biomarker; Nephrectomy

Study type: Observational

Funder types: Other

Identifiers

NCT07088874

2025-067

Details and patient eligibility

About

The incidence of acute kidney injury (AKI) after radical nephrectomy exceeds 40%. Currently, the KDIGO criteria are the recognized diagnostic standard for AKI. These criteria primarily use serum creatinine and urine output as key indicators, but both parameters have certain limitations, such as delayed response, insensitivity, and inaccuracy. This study aims to simultaneously monitor perioperative novel renal damaging, stressful, and functional biomarkers in patients undergoing radical nephrectomy, and to investigate their predictive value for AKI and postoperative 1-year chronic kidney disease (CKD).

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥18 years;
• Scheduled to undergo unilateral radical nephrectomy.

Exclusion criteria

• Solitary kidney;
• Preoperative diagnosis of chronic kidney disease stages G4 or G5 (GFR <30 mL/min/1.73m²);
• Tumor invasion of the vena cava requiring thrombectomy;
• Other conditions deemed by the investigator as unsuitable for participation in this study.

Trial design

60 participants in 2 patient groups

AKI group/CKD group

Description:

1. patients diagnosed with AKI after radical nephrectomy. 2. patients diagnosed with the new onset/worsening of CKD after radical nephrectomy.

non-AKI group/non-CKD group

Description:

1. patients without AKI after radical nephrectomy. 2. patients without new onset/worsening of CKD after radical nephrectomy.