Novel Controlled Hypo-Perfusion Technique in Partial Nephrectomy

University Health Network, Toronto

Status and phase: Terminated; Phase 2

Conditions: Partial Nephrectomy; Renal Cell Carcinoma

Treatments: Procedure: Hypoperfusion of renal artery

Study type: Interventional

Funder types: Other

Identifiers

NCT01720693

Hypoperfusion

Details and patient eligibility

About

Many patients who are candidates for nephron-sparing surgery, partial nephrectomy is now the standard treatment with a surgical, small, clinical T1 tumor (<7 cm). In many recent studies, partial nephrectomy provides equivalent oncologic, and superior functional, outcomes compared with the standard radical nephrectomy over the short and long term (2, 3). Partial nephrectomy techniques, whether open, laparoscopic or robotic, typically involve hilar clamping, which creates the desired bloodless operative field, allowing for more precise tumor excision and renal reconstruction. This hilar clamping eventually may lead to ischemic kidney injury which can compromise the functional outcomes of the remaining kidney.We are working now to develop a novel technique of Hypo-Perfusion by achieving partial renal arterial clamping, with the goal of completely eliminating surgical ischemia to the renal remnant.

Enrollment: 3 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient must be at least 18 years old scheduled for open partial nephrectomy

Exclusion criteria

• No prior diagnosis of renal artery disease

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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3 participants in 1 patient group

hypoperfusion

Experimental group

Description:

Hypoperfusion of the renal artery

Treatment:

Procedure: Hypoperfusion of renal artery