Novel Dementia Biomarkers

German Center for Neurodegenerative Diseases (DZNE)

Status: Unknown

Conditions: Alzheimer Disease, Early Onset

Treatments: Other: No Intervention

Study type: Observational

Funder types: Other

Identifiers

NCT04427436

MD070

Details and patient eligibility

About

The study will investigate structural and functional characteristics of the brain of dementia patients compared to healthy controls in order to get a better insight into importance of early biomarkers for the diagnosis of Alzheimer's dementia. The methods for obtaining biomarkers incude magnetic resonance imaging (MRI), near-infrared spectroscopy (fNIRS) and electroencephalography (EEG), electrocardiography (ECG) and neurophyshological assessments. Special parameters are being studied that have already been shown to detect changes in the early stages of Alzheimer's dementia.

Enrollment: 100 estimated patients

Sex: All

Ages: 50 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinically diagnosed MCI patients and matched healthy controls

Exclusion criteria

• Metal in body and tatoos;
• Other chronic systemic neurological, cardiologic, metabolic or musculo-skeletal diseases which have been proven to influence the outcome variables
• Alcohol abuse
• Colour blindness
• Pregnancy
• Surgery in the last 6 months
• Uncorrected vision

Trial design

100 participants in 2 patient groups

Patients

Description:

Mild Cognitive Impairment (clinical determination)

Treatment:

Other: No Intervention

Control

Description:

Healthy Elderly

Treatment:

Other: No Intervention