Novel Equations for Estimating Lean Body Mass in Patients With Chronic Kidney Disease

Peking University

Status: Completed

Conditions: Chronic Kidney Diseases; Lean Body Mass

Study type: Observational

Funder types: Other

Identifiers

NCT04074278

LBM eqations

Details and patient eligibility

About

Simplified methods to estimate lean body mass (LBM), an important nutritional measure representing muscle mass and somatic protein, are lacking in non-dialyzed patients with chronic kidney disease (CKD).

Objective: We developed and tested a reliable equations for estimation of LBM in daily clinical practice.

Full description

Two cross-sectional data sets were derived from outpatients with CKD stage 3-5 in Peking University First Hospital.Two equations for estimating LBM based on midarm muscle circumference (MAMC) or hand grip strength (HGS)were developed and validated in CKD patients with dual-energy x-ray absorptiometry (DEXA) as referenced gold method. Demographic data, comorbidity, and other clinical variables were also recorded.

Enrollment: 300 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• non-dialyzed patients with CKD stage 3-5
• clinical stable
• a willingness to be examined with all measurements being taken simultaneously.

Exclusion criteria

• systemic infections, acute cardiovascular events, operations, trauma, active hepatitis or tumor
• severe edema within one month prior to the study
• chronic infections, connective tissue disease, hyper- or hypothyroidism, amputations or pregnancy,
• taking immunosuppressive agents and anti-inflammatory medication chronically

Trial design

300 participants in 2 patient groups

development groups

Description:

The development groups included 150 patients derived from outpatients in Peking University First Hospital, between March 1st, 2014 and November 26th 2014.

validation groups

Description:

The validation groups included 150 patients derived from outpatients in Peking University First Hospital, between November 27th 2014 and December 1st, 2015.