Novel Imaging Techniques for the Characterization of Musculoskeletal Tumors II (TUMOSTEO II)

Central Hospital, Nancy, France

Status: Enrolling

Conditions: Bone Neoplasm; Soft Tissue Neoplasm

Treatments: Diagnostic Test: MR imaging

Study type: Observational

Funder types: Other

Identifiers

NCT04394052

2019PI253

Details and patient eligibility

About

This study aims at evaluating the value of various artificial intelligence based techniques to improve the characterization and image post-processing for patients with musculoskeletal tumors.

Full description

Comparison of values relating to the texture parameters of tumors evaluated by MRI and ultra-high resolution CT between benign and malignant lesions using histological analysis as the standard of reference.

Comparison of the diagnostic performance of texture parameters derived from different MRI sequences and ultra-high resolution CT for musculoskeletal tumor characterization.

Evaluate the impact of ultra-high resolution with respect to standard resolution on CT images Comparison of the diagnostic performance of the texture parameters for the tumor on the diagnostic performance of texture analysis derived parameters for the characterization of musculoskeletal tumors.

Evaluate the effectiveness and accuracy of automatic artificial intelligence (AI) based tumor segmentation tools.

Evaluate the use of trabecular analysis on ultra-high resolution CT images for the evaluation of tumor-bone interfaces.

Enrollment: 740 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients suspected to have a bone or soft-tissue tumor referred for imaging for initial tumors characterization and staging.

Exclusion criteria

• Pregnancy
• Breast feeding patients
• Renal insufficiency
• Contra indications to MRI or CT
• Prior surgery or treatment to the evaluated lesion.

Trial design

740 participants in 2 patient groups

Soft-tissue tumors

Description:

Benign and malignant soft tissue masses

Treatment:

Diagnostic Test: MR imaging

Bone tumors

Description:

Benign and malignant bone focal bone lesions

Treatment:

Diagnostic Test: MR imaging