Novel Listeria Vectors Secreting Gut Flora-Altering Agents to Prevent Colon Cancer and Treat Colitis

The University of Texas System (UT)

Status: Withdrawn

Conditions: Colon Cancer; Colitis

Study type: Observational

Funder types: Other

Identifiers

NCT03014284

CTMS 16-0101

HSC20160555H (Other Identifier)

Details and patient eligibility

About

This is a simple tissue collection study with no therapeutic intent. Colon tissues will be taken from standard of care procedures. Tissues will be tested for their functions, expression of immune co-signaling molecules and reactions to transduction with recombinant Listeria vectors to assess effects on expression of B7-H1 and cytokines.

Sex: All

Ages: 18 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Able to provide informed consent (or have consent provided through a guardian)
• No immune-modulating drug use during study or within 30 days prior to enrollment
• Having colon material collected as part of standard of care

Exclusion criteria

• Unable to provide informed consent (or have consent provided through a guardian)
• Not having colon material collected as part of standard of care