Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy

Englewood Hospital and Medical Center

Status: Enrolling

Conditions: Liver Cancer Adult; Liver Regeneration

Treatments: Other: carbon monoxide measurement via smokerlyzer

Study type: Interventional

Funder types: Other

Identifiers

NCT06681818

E-24-982

Details and patient eligibility

About

the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO in patients following liver resection and correlate these findings to the rate of liver regeneration and liver function.

Enrollment: 125 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient plans to have partial liver resection for primary liver pathology or metastatic disease
• Patient is able to comprehend and willing to sign the written consent form

Exclusion criteria

• Patients < 18 years
• Patients identified as members of a vulnerable population, except women of child bearing potential with negative pregnancy test

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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125 participants in 1 patient group

all participants

Experimental group

Description:

all participants will provide breath samples to detect carbon monoxide levels

Treatment:

Other: carbon monoxide measurement via smokerlyzer