Novel Oxygenation Indices in Robot-Assisted Laparoscopic Surgeries

Başakşehir Çam & Sakura City Hospital

Status: Completed

Conditions: Ventilator-Induced Lung Injury

Treatments: Procedure: T0 Time; Procedure: Tint Time; Procedure: T1

Study type: Observational

Funder types: Other

Identifiers

NCT06430606

2024-05-

Details and patient eligibility

About

In this study, changes in new oxygenation indices investigated by Asar et al. will be compared with conventional oxygenation and saturation indices in patients undergoing robot-assisted laparoscopic surgery due to pneumoperitoneum and Trendelenburg position.

Full description

During the intraoperative period, optimal oxygenation should be achieved while avoiding the harmful effects of hypoxia and hyperoxia in patients. The PaO2/FiO2 and SpO2/FiO2 ratios have been traditionally used to assess this condition. Subsequently, oxygenation indices incorporating mean airway pressure have been developed, such as the oxygenation index (OI = (FiO2 × Pmean) / PaO2) and oxygenation saturation index (OSI = (FiO2 × Pmean) / SpO2). More recently, Asar et al. have defined 8 novel oxygenation indices using mean power (MP) and driving pressure (DP) instead of Pmean (OSI-MPtot, OI-MPtot, OSI-ΔPinsp, OI-ΔPinsp, OSI-MPdyn, OI-MPdyn, PaO2/(FiO2xPEEP), and SpO2/FiO2xPEEP). They compared the predictive power of these new indices for intensive care unit (ICU) mortality in COVID-ARDS (C-ARDS) patients with conventional oxygenation indices (PaO2/FiO2, SpO2/FiO2, OI, OSI). OI-ΔPinsp, OSI-ΔPinsp, and OSI-MPdyn indices were found to have the highest predictive power for ICU mortality. However, there is currently no study investigating the changes of these new indices during the intraoperative period.

Enrollment: 56 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA (American Society of Anesthesiologists) class I-III
• Age between 18-75 years
• Signed informed consent form

Exclusion criteria

• Diagnosis of COPD (Chronic Obstructive Pulmonary Disease) and asthma
• History of thoracic surgery
• Body mass index (BMI) > 35
• Development of hemodynamic instability or desaturation (SpO2 < 92) during the operation

Trial design

56 participants in 1 patient group

Patients undergoing robotic-assisted laparoscopic surgery

Description:

The patients consist of ASA I-II or III group undergoing robotic-assisted laparoscopic surgery.

Treatment:

Procedure: T1

Procedure: Tint Time

Procedure: T0 Time