NSAIDs Treatment in Children With Pleuropneumonia

Clalit Health Services

Status: Unknown

Conditions: Pleuro-pneumonia

Treatments: Drug: Ibuprofen; Drug: Acetaminophen

Study type: Interventional

Funder types: Other

Identifiers

NCT01586299

262-11-RMC

Details and patient eligibility

About

The purpose of this study is to evaluate the influence of routine NSAIDs treatment for hospitalized children with pleuropneumonia in comparison with acetominophen treatment (all in conjunction with adequate antibiotic therapy).

Enrollment: 40 estimated patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age less than 18 years
• admission in Schneider childrenMC of Israel, wards a/c
• clinical diagnosis of pneumonia with evidence of pleural effusion on chest X-ray
• parental informed consent
• follow-up ability after discharge

Exclusion criteria

• pneumonia secondary to foreign body aspiration
• immune deficiency
• chronic lung disease other than asthma (CF, CLD of prematurity, Familial Dysautonomia, etc)
• significant premorbidity (organ failure, rheumatic disease, etc)
• endotracheal/endobronchial devices including tracheostomy.
• parental refusal to participate in the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

ibuprofen

Experimental group

Treatment:

Drug: Ibuprofen

acetaminophen

Active Comparator group

Treatment:

Drug: Acetaminophen