NT-proBNP and New Biomarkers in Patients With Dyspnea and/or Peripheral Edema (MANPRO)

Universitätsmedizin Mannheim

Status

Completed

Conditions

Dyspnea

Peripheral Edema

Study type

Observational

Funder types

Other

Identifiers

80/05

Details and patient eligibility

About

The objectives of this study are to:

Evaluate the sensitivity and specificity of NT-proBNP (N-terminal prohormone brain natriuretic peptide) and new biomarker measurements for the diagnosis of heart failure in patients with acute dyspnea and/or edema.
Determine the exact biomarker cut-off point(s) for the differentiation of healthy persons, patients with heart failure and patients with dyspnea of other origin.
Evaluate treatment costs in patients with dyspnea under special consideration of NT-proBNP measurement.

Full description

Primary endpoint:

Sensitivity and specificity of biomarker measurements for discrimination of heart failure from dyspnea of other origin.

Secondary endpoints:

Determination of Cut-off(s)
Discrimination of cardiac and non-cardiac diseases causing to dyspnea or peripheral edema
Determination of treatment costs of the initial hospital stay
Evaluation of resource savings when implementing NT-proBNP for determination of diagnosis.
Time to diagnosis.
Hospitalization rate /Intensive care treatment rate between day 1 and 28
Duration of initial hospital stay
30-day re-hospitalization rate
30 day mortality rate and adverse event rate
1 and 5 year mortality rates
1 and 5 year rehospitalization rates