Nuclear Factor Kappa-B (NFKB1) Polymorphism and Organ Injury After Cardiac Surgery

Naval Military Medical University

Status: Completed

Conditions: Acute Lung Injury; Kidney Injury; Single Nucleotide Polymorphism

Study type: Observational

Funder types: Other

Identifiers

NCT00819871

PCSP-NFKB1

Details and patient eligibility

About

NFKB1 -94ins/del polymorphism has been reported to be associated with reduced promoter activity of NFKB1 and several clinical diseases, but the clinical results cannot always be replicated. Besides, mutate allele is associated with alleviated inflammation in ulcerative colitis and some tumors, but aggravated inflammation in ARDS. The clinical value of this polymorphism remains controversial. This study was performed to investigate the association of NFKB1 -94ins/delATTG polymorphism with lung and/or kidney injury after cardiac surgery with CPB.

Enrollment: 105 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chinese Han unrelated population
• undergoing elective cardiac surgery with CPB

Exclusion criteria

• malignant tumor
• autoimmune disease, immunodeficiency or immunosuppressive therapy
• chronic renal disease (glomerular filtration rate < 60ml/(min•1.73m2)) or liver dysfunction (Child Pugh classification>A)
• COPD, tuberculosis or other chronic pulmonary diseases
• anemia with hemoglobin lower than 90mmHg
• bleeding disorders
• postoperative pericardial tamponade requiring re-operation
• postoperative low cardiac output syndrome or acute pulmonary edema after left cardiac failure.

Trial design

105 participants in 4 patient groups

PLI

Description:

patients with postoperative lung injury

without PLI

Description:

patients without postoperative lung injury

PLI/PKI

Description:

patients with at least one organ injury of lung or kidney after surgery

without PLI/PKI

Description:

patients without lung or kidney injury after surgery