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Nudging Providers to Curtail Dangerous Opioid Prescribing: A Trial to Investigate Mechanisms

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Columbia University

Status

Completed

Conditions

Opioid Use

Treatments

Behavioral: PMP Use Mandate Letter
Behavioral: Prescribing Information + PMP Use Mandate Letter
Behavioral: Prescribing Information Letter

Study type

Interventional

Funder types

Other

Identifiers

NCT04628832
AAAT2489

Details and patient eligibility

About

Despite an enormous policy response, opioid prescribing remains well above historical levels and harms from opioids continue to mount. Nearly all states have Prescription Monitoring Programs (PMPs) to facilitate safer prescribing of opioids and other drugs, but research suggests these systems only deliver benefits when health care professionals are required to use them. Even with PMP mandates in place, providers may be unaware of the dangers of co-prescribing opioids with benzodiazepines or gabapentinoids, which include increased risk of overdose and death. Working with the Minnesota state government, the investigators will mail letters to guideline-discordant opioid prescribers that either highlight an upcoming legally mandated requirement to check the PMP before prescribing an opioid, inform and educate providers about patients filling concurrent prescriptions and the dangers of such co-prescribing, or both. Study participants will be randomized to receive no intervention or one of the three treatment letters. Using administrative data, the investigators will track effects of the letters on not only prescribing but also PMP usage and queries. Findings form the multiplicity of treatment messages and outcomes will shed light on the mechanisms driving overprescribing. Results will inform future work by state and local policymakers to make opioid prescribing safer.

Enrollment

12,000 patients

Sex

All

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Wrote concurrent prescription for opioids and benzodiazepines OR opioids and gabapentinoids

Exclusion criteria

  • Specialization in oncology or palliative medicine

Trial design

Primary purpose

Health Services Research

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

12,000 participants in 4 patient groups

PMP Use Mandate
Experimental group
Treatment:
Behavioral: PMP Use Mandate Letter
Prescribing Information
Experimental group
Treatment:
Behavioral: Prescribing Information Letter
Prescribing Information + PMP Use Mandate
Experimental group
Treatment:
Behavioral: Prescribing Information + PMP Use Mandate Letter
Control / As-Usual
No Intervention group

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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