Number of Multiple Breath Washout Tests in Adults With Pulmonary Disease and Healthy Controls

Universitätsmedizin Mannheim

Status: Completed

Conditions: Sarcoidosis; Bronchial Asthma; Chronic Obstructive Pulmonary Disease; Healthy Controls

Treatments: Diagnostic Test: multiple breath washout

Study type: Observational

Funder types: Other

Identifiers

NCT03176745

MBW-number

Details and patient eligibility

About

The investigators aim to determine the optimal number of measurements required for multiple-breath-washout derived lung function parameters in adults with pulmonary disease as well as in healthy controls

Enrollment: 153 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• informed consent

Exclusion criteria

• inability to perform multiple breath washout testing

Trial design

153 participants in 4 patient groups

healthy controls

Description:

* no history of pulmonary disease * absence of symptoms, smoking history \< 10 pack years * normal lung function testing

Treatment:

Diagnostic Test: multiple breath washout

chronic obstructive pulmonary disease

Description:

* clinical history and/or specialist diagnosis of COPD and risk factor(s) * persistent bronchial obstruction and/or hyperinflation and/or radiological sign of emphysema, each without alternative explanation * dyspnea, cough and/or sputum production

Treatment:

Diagnostic Test: multiple breath washout

bronchial asthma

Description:

* clinical history and/or specialist diagnosis of bronchial asthma * respiratory symptoms compatible with asthma varying over time * variable and/or reversible obstructive ventilation disorder and/or airway hyperresponsiveness * exclusion of alternative explanation

Treatment:

Diagnostic Test: multiple breath washout

sarcoidosis

Description:

* clinical history and/or specialist diagnosis of sarcoidosis * lymphocytic alveolitis and CD4/CD8 \> 3.5 in bronchoalveolar lavage and/or noncaseating epithelioid granuloma * exclusion of alternative explanation

Treatment:

Diagnostic Test: multiple breath washout