Nurse Managed Sequential Strength Training and Bicycle Training in Chronic Obstructive Pulmonary Disease (COPD)

University of Illinois

Status and phase: Completed; Phase 2

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Behavioral: Resistance training; Behavioral: Aerobic training

Study type: Interventional

Funder types: Other

Identifiers

NCT01058213

NR010249

Details and patient eligibility

About

This is a 16 week exercise training program for people with severe to very severe chronic obstructive pulmonary disease (COPD). The purpose of this study is to find out if performing strength training prior to initiating exercise training on a stationary bicycle is associated with greater gains in functional status than bicycle training alone or concurrent bicycle and strength training together.

Full description

Volunteers are randomly assigned to one of three groups: 1). 8 weeks of resistance (strength) training followed by 8 weeks of bicycle exercise training, 2). 8 weeks of chair exercise followed by 8 weeks of resistance (strength) training and bicycle exercise training, or 3). 8 weeks of chair exercise followed by 8 weeks of bicycle exercise training. The length of the training is 16 weeks for all 3 groups. Volunteers train 3 days per week in our lab located in the Chicagoland area and are supervised by an exercise specialist.

Enrollment: 354 patients

Sex: All

Ages: 46+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• FEV1/FVC < 70 and FEV1 < 55%,
• > 45 years of age,
• experience dyspnea with exertion,
• stable clinical condition (Stable clinical condition is defined as free of respiratory tract infections for at least two months prior to enrollment, no recent change in the color, consistency, or quantity of sputum, afebrile and no recent change in medical therapy.)

Exclusion criteria

• evidence of restrictive lung disease or asthma,
• acute respiratory infection,
• taking oral corticosteroids on a regular basis,
• >3 exacerbations in the previous year,
• currently participating in pulmonary rehabilitation,
• the presence of a potentially debilitating disease or the presence of a condition that would make it potentially unsafe to exercise.
• We will adhere to the American College of Sports Medicine guidelines and exclude those who do not meet their guidelines for exercise testing and training.
• Pregnant women or women who plan to become pregnant during the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

354 participants in 3 patient groups

Aerobic training alone

Active Comparator group

Description:

8 weeks of gentle chair (sham) training followed by 8 weeks of interval aerobic training on a stationary bicycle

Treatment:

Behavioral: Aerobic training

Sequential Resistance then Aerobic Training

Experimental group

Description:

8 weeks of resistance training of the lower body followed by 8 weeks of interval aerobic training on a stationary bicycle

Treatment:

Behavioral: Resistance training

Behavioral: Aerobic training

Concurrent resistance and aerobic training

Active Comparator group

Description:

8 weeks of gentle chair (sham) exercise followed by 8 weeks of concurrent resistance training of the lower body and interval aerobic training on a stationary bicycle

Treatment:

Behavioral: Resistance training

Behavioral: Aerobic training