Nutrient Levels Alter Transplant Outcome

University of Cincinnati

Status: Completed

Conditions: Chronic Renal Disease

Treatments: Dietary Supplement: Coromega and Arginine; Dietary Supplement: Arginine and canola oil

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00560014

5U01AI040167 (U.S. NIH Grant/Contract)

LIPIDS

R03 AI142743

Details and patient eligibility

About

The purpose of this study is to look at lipid profiles of plasma and RBC and amino acid profiles in plasma to determine if they are associated with allograft rejection, calcineurin inhibitor toxicity or new onset diabetes mellitus in renal transplant patients receiving dietary supplements with arginine and omega-3 fatty acids.

Enrollment: 54 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Renal transplant recipient
• Appropriate blood samples drawn and analyzed

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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54 participants in 3 patient groups

1

Experimental group

Description:

Arginine and Canola oil supplemented group

Treatment:

Dietary Supplement: Arginine and canola oil

2

Experimental group

Description:

Arginine and Coromega

Treatment:

Dietary Supplement: Coromega and Arginine

3

No Intervention group

Description:

Control