Nutrient Mixtures and Neurodevelopment

Mount Sinai Health System

Status: Completed

Conditions: Neurodevelopment

Treatments: Other: Nutrient mixtures

Study type: Observational

Funder types: Other

Identifiers

NCT03420872

GCO 12-1417

Details and patient eligibility

About

Background: Adequate levels of beneficial nutrients are important for neurodevelopment. Although, nutrients are ingested in combination, considering nutrients as a mixture has not been studied with respect to health, such as neurodevelopment.

Objective: To examine the impact of prenatal and childhood nutrition mixtures on neurodevelopment.

Design: Participants included mother-child pairs in the Programming Research in Obesity, Growth Environment and Social Stress (PROGRESS) prospective birth cohort in Mexico City. Prenatal and child nutrition profiles were assessed among 65 and 329 children respectively by analyzing components of a food frequency questionnaire. Child neurodevelopmental outcomes at 4-6 years of age were measured using the McCarthy Scales of Children's Abilities (MSCA).

Enrollment: 329 patients

Sex: All

Ages: 18 to 44 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Women of children:

• less than 20 weeks gestation at the start of the study
• at least 18 years of age
• and planned to reside in Mexico City for the next three years.

Exclusion criteria

Women of children:

• free of heart or kidney disease
• not use steroids or anti-epilepsy drugs
• not consume alcohol.

Trial design

329 participants in 1 patient group

Subset from PROGRESS cohort

Description:

Participants included children 4-6 years of age from mother-child pairs in the Programming Research in Obesity, Growth Environment and Social Stress (PROGRESS) prospective birth cohort in Mexico City

Treatment:

Other: Nutrient mixtures